Most women experience menopausal symptoms such as hot flashes, emotional instability, and memory loss during the perimenopause. Some men over the age of 40 also often complain of symptoms similar to those of menopause in women, such as decreased libido, irritability, sweating, fatigue, and memory loss. Does men have menopause too? As early as the 1930s, Western scholars discovered that some middle-aged and older men had symptoms similar to those of women going through menopause, and named the disease “male menopause syndrome” at that time. Since then, the syndrome has been named “andropause” and “partial androgen deficiency syndrome in middle-aged and elderly men” until 2002, when the International Society for the Study of Aging Men (ISSAM) named the syndrome “LOH is an age-related clinical and biochemical syndrome characterized by clinical symptoms and decreased serum testosterone levels (below the normal reference range for young healthy adult men), which seriously affects the quality of life of patients and adversely affects the function of various organs and systems of the body. This state has a serious impact on the quality of life of patients and adversely affects the function of many organs and systems of the body. For various reasons, this disease is not yet widely recognized. The core problem of LOH is the gradual decrease in serum testosterone levels in adult men as they age (especially after the age of >40 years). A clinical cross-sectional study of 1709 men in Massachusetts, USA, showed that total testosterone (TT) and free testosterone (FT) in men decreased at a rate of 0,4% and 1,2% per year, respectively. Testosterone has direct or indirect effects on all systems of the body. Testosterone deficiency will lead to abnormalities in the body’s bones, muscles, fat, blood and cardiovascular tissues and organs, as well as emotional and cognitive functions, and a series of problems in sexual function. Specific performance can be as follows: 1, sexual dysfunction: mainly manifested as decreased libido, the number of erections and erectile hardness at night, erectile dysfunction; 2, physical decline: general weakness, easy fatigue; 3, mental and psychological disorders: poor mental state, inattention, forgetfulness, insomnia, depressed mood, irritability, irritability, depression, etc.; 4, vasodilatory symptoms: hot flashes, excessive sweating and facial redness. Other symptoms: trunk obesity, low back pain, limb and joint pain. In severe cases, it can lead to osteoporosis, and minor trauma can lead to fracture. Some patients may also show breast development, insulin resistance, and even many symptoms of type 2 diabetes and metabolic syndrome. The above symptoms can be evaluated by questionnaires (e.g. AMS scale). Patients suspected of LOH should also have their serum testosterone levels checked, and experimental testosterone supplementation can be considered for suspected cases. Proper and reasonable testosterone supplementation can significantly improve the symptoms and signs associated with androgen deficiency and restore good living conditions. The benefits of testosterone supplementation therapy include: improving patients’ bone density, alleviating osteoporosis, increasing lean body mass, improving muscle strength, reducing visceral fat, increasing libido and sexual frequency, improving penile erectile function, increasing sensitivity to insulin, and improving metabolic status. Testosterone supplementation therapy requires strict indications, during which close follow-up is needed to monitor the efficacy and possible side effects. At present, there are about 1.5-200 million men older than 50 years old in China, and a significant proportion of them have the above-mentioned “menopausal” health problems. With the accelerated aging of China’s population, the problem of “male menopause” in middle-aged and elderly men will become a major public health problem that requires our utmost attention.