Hypothermia and cold hands and feet are usually caused by the following four reasons: First, endocrine metabolic diseases, there can be hypothyroidism, low adrenocortical function and lower basal metabolic rate, resulting in hypothermia accompanied by cold hands and feet. Second, peripheral circulatory dysfunction, when the fever is low, but the peripheral nerve circulation function is reduced, so the hands and feet are cold. Third, often viral infections cause hypothermia accompanied by cold hands and feet, common diseases include viral pneumonia, viral nephritis and viral enteritis. Fourth, rare diseases such as anemia, tumors, immune tissue insufficiency, connective tissue diseases, and rheumatism can also have hypothermia accompanied by cold hands and feet.