If penile cancer is removed cleanly by surgery, and if the tumor has not metastasized and there is no other serious disease, the life expectancy of patients can be the same as that of normal people in general, otherwise it may affect the life expectancy of patients. If penile cancer is in the early stage and the tumor has not metastasized, most of the patients can be cured after surgical resection and the prognosis is good. If the tumor is removed after surgery, most patients can be cured and the prognosis is good. With good postoperative care and follow-up, the life expectancy of patients will not be affected and they can basically live as normal people. If the tumor is in the middle or late stage, metastasis may occur, and there may be complications or recurrence, even after radiotherapy, targeted therapy, etc., it is still difficult to cure. Therefore, it is difficult for patients to live as normal people, which will reduce the quality of life and life expectancy. Penile cancer patients should have regular review after surgery to find out early recurrence; keep optimistic mentality and ensure sufficient nutrition; exercise appropriately to enhance physical fitness and so on. If there is any physical discomfort, they should go to regular hospitals in time and be treated under the guidance of doctors.