Patients with advanced penile cancer can have surgical treatment, radiotherapy and chemotherapy. 1. Surgical treatment: the treatment of primary foci should firstly ensure that the cutting edge is free of tumor, followed by function and appearance. Advanced patients can have palliative penile lesion excision, supplemented by postoperative radiotherapy and chemotherapy. 2. Radiotherapy: pure radiotherapy for advanced tumors is usually ineffective and should be used as postoperative adjuvant therapy. Small superficial tumors respond better to radiotherapy and have low complications. For tumors <4cm in diameter, brachytherapy can achieve a high local control rate; for larger invasive penile cancer, the treatment effect is not satisfactory. 3. Chemotherapy: chemotherapy is usually given to patients with inoperable resection, multiple inguinal or pelvic lymph node metastasis and distant metastasis. Since single-drug therapy is not effective for penile cancer, multi-drug combination therapy is commonly used. MBP regimen containing cisplatin (methotrexate + bleomycin + cisplatin) or VBM regimen (vincristine + bleomycin + methotrexate) are commonly used. Chemotherapeutic agents have more adverse effects and should be used in accordance with medical advice. Patients with advanced penile cancer should follow the doctor's prescription for treatment, often using surgery combined with radiotherapy and chemotherapy integrated treatment, active treatment can prolong the survival of patients.