What causes chronic renal failure to occur? In general, chronic renal failure usually progresses slowly, taking years or even decades to develop into uremia. However, in clinical practice, we often encounter patients whose kidney function progresses rapidly within days, weeks or months, even to uremia. Most of these cases have obvious triggers, and timely detection and removal of these triggers can also save kidney function. These causative factors include: ① the primary disease activity involving the kidney or poorly controlled condition, such as various nephritis activity, hypertension, poorly controlled diabetes; ② insufficient blood volume, such as vomiting and diarrhea or massive diuresis causing dehydration, hemorrhage, hypotension, etc. The cause of the short-term deterioration of renal function in the above cases may be related to the patient’s vomiting and diarrhea causing dehydration; ③ severe hypertension is not controlled, especially if the blood pressure continues to (3) Severe hypertension is not controlled, especially when the blood pressure is above 180/120 mmHg; (4) Heart failure or severe arrhythmia; (5) Use of nephrotoxic drugs, such as certain antibiotics, painkillers, contrast agents, some herbal medicines containing aristolochic acid; (6) Urinary tract obstruction, such as urinary stones, prostate hypertrophy; (7) Various infections, including respiratory, digestive, urinary tract or skin infections; (8) High protein diet; (9) Electrolyte disorders, such as high blood calcium or High blood phosphorus; ⑩Acute stress, such as trauma, major surgery, etc. When these acute factors are present, renal function may deteriorate dramatically and even threaten the life of the patient. For acute exacerbation of renal function in the course of chronic renal failure, it is possible to reverse renal function and not enter into irreversible uremia if the causative factors are removed and treated appropriately.