There are no studies showing that metformin glibenclamide capsules can cause vitiligo. Metformin glibenclamide capsule is a kind of oral hypoglycemic drug, which mainly contains metformin and glibenclamide, used to lower blood sugar, the common side effects of this drug are shown in the following aspects: 1. Hypoglycemic reaction: panic, cold sweat, hand shaking, hunger, and in severe cases, loss of consciousness may occur, especially when patients have insufficient calorie intake or after strenuous exercise, hypoglycemia is more likely to occur. 2. It may cause liver and kidney function damage. 3. Gastrointestinal reactions: such as epigastric discomfort, nausea, vomiting and diarrhea. 4. Anemia: the drug may cause gastrointestinal vitamin B12 absorption disorder, resulting in megaloblastic anemia. Therefore, metformin glibenclamide capsules generally do not cause vitiligo, patients who need to take metformin glibenclamide capsules are advised to follow medical advice.