Mr. Zhang was in his early 40s and had chronic viral hepatitis B (minor triplet), but he was not in obvious discomfort and was busy with his business, so he had not had a medical checkup for several years. Even if the liver area appears vague swelling pain for more than 1 month, but also did not go to the doctor. It was only when the abdominal pain and distension increased, he had difficulty sleeping at night and his lower limbs were swollen that he went to the hospital, and ultrasound and enhanced CT examination revealed a huge cancer in the right liver with intrahepatic metastases and ascites. When his family found me to see the doctor, it was obvious that the cancer could no longer be surgically removed. Later, Mr. Zhang went to a hospital in Shanghai for an interventional embolization chemotherapy of the liver, but the outcome was poor, and he passed away in less than 4 months from the diagnosis of primary liver cancer. In clinical practice, we often encounter advanced liver cancer cases like Mr. Zhang, and the prognosis is often poor even though both doctors and patients have put in great efforts. The survival period of patients with advanced liver cancer is usually within six months. According to the 2012 China Tumor Registry Annual Report, the chance of death due to cancer in China is 13%, that is, one out of every 7-8 people dies of cancer, and liver cancer takes the second place in the mortality rate of malignant tumors, and 260,000 people die of liver cancer in China every year. However, liver cancer is not an incurable disease, early diagnosis and early treatment can prolong life. A patient in his 50s was found to have hepatocellular carcinoma with a tumor size of 2.5cm×2cm during physical examination 8 years ago, and subsequently underwent laparoscopic left hepatic lobectomy. It has been reported in the literature that the 5-year survival rate after radical surgical resection of small hepatocellular carcinoma less than 5 cm in diameter is 72.9%, and the 5-year survival rate after surgical resection of microscopic hepatocellular carcinoma less than 2 cm is 86.4%. How to detect and diagnose liver cancer at an early stage? First, let’s understand the symptoms of liver cancer. Pain and discomfort in the right upper abdomen and liver area are the most common, followed by weakness, emaciation, loss of appetite, abdominal distension and fever. When the above symptoms appear, it is important to be alert and strive for early detection. Unfortunately, the early symptoms of liver cancer are usually hidden, and many liver cancer patients have almost no symptoms in the early stage, and when obvious liver cancer symptoms appear, they are already in the middle or late stage. In fact, the early detection of liver cancer is basically through physical examination. Therefore, it is important to pay attention to health checkups, which is more necessary for people with high risk of liver cancer. People with the following characteristics belong to the high-risk group of liver cancer: chronic hepatitis history for more than 5 years; long-term alcoholics; family members who have been diagnosed with liver cancer; long-term consumption of pickled, smoked and moldy foods; long-term work stress, excessive workload or long-term mental depression. In China, viral hepatitis is the primary factor in the development of liver cancer, and most liver cancer patients have a history of hepatitis B. Hepatitis, cirrhosis and liver cancer are recognized as the “trilogy” of liver cancer evolution. AFP test. For about 60% of people at high risk of liver cancer in China, AFP is a very practical test to make early diagnosis of liver cancer six months to one year before the appearance of liver cancer symptoms. For early stage liver cancer with no symptoms, liver ultrasound and fetoprotein test can screen out most small liver cancers. Further diagnosis of liver cancer can be made by liver CT or magnetic resonance imaging (MRI). Early surgical resection is still the preferred and most effective treatment method.