1, brucellosis with prolonged fever mostly flaccid fever part of the wave type of the most specific multiple joint pain testicular inflammation sweating more than a history of contact with sick cows and sheep serum agglutination test helps diagnosis. 2, scrub typhus for scrub typhus rickettsiae infection vector chiggers mite larvae bite appear papules into sores after rupture central necrosis brown scabs called scorch idiocy scorch scabs near the lymph node swelling pressure and pain not pus the whole body of the superficial lymph nodes mildly enlarged rash often appeared in the first 5 to 7d patchy rash or maculopapular rash chest, back and abdomen, more in some cases can be liver and spleen enlargement of natural course of the disease in about 3 weeks of exophthalmos reaction Oxk strain positive can be diagnosed. 3, rubella Rubella is a common respiratory infection caused by rubella virus, most commonly seen in children with lymph node swelling and rash at the same time with diagnostic significance after 1 to 2 fever, the rash quickly covered the trunk and limbs, palms and soles of the feet are often no rash lymph node enlargement is most common in the back of the ear under the occipital bone, posterior neck as a feature of the rash usually lasts 3 d after subsiding the enlarged lymph nodes often take several weeks to fully recover. 4.Measles Most commonly seen in children with fever and upper respiratory tract symptoms of kata Measles Department of membrane spots (Koplik spots) for the early features of the disease fever 3 ~ 5d rash palms and soles of the feet also have a rash rash when the rash of the whole body lymph nodes and liver can be enlarged. 5, cat scratch disease mainly through the cat’s scratching and biting caused by the acute infectious diseases used to think that a virus is now more inclined to a small polymorphic gram-negative bacillus is scratched skin can be seen herpes pustules scabs or small ulcers can be formed for several weeks of microfebrile scratches in the corresponding drainage area of the lymph node enlargement and tenderness, and some of the lymph nodes can be suppurative specific antigen intradermal test positive. Bacterial culture of pus is negative and silver saturation staining reveals polymorphic gram-negative bacilli. 6.Leptospirosis often has pain and pressure in the pedal muscle hemoptysis gangrene local lymph node enlargement accounts for 20% of the total body lymph node enlargement 15% most common is inguinal lymph node followed by axillary lymph node leptospirosis agglutination and lysis test more than 1:400 potency for positive has high specificity and sensitivity. 7.Scarlet fever Lymph node enlargement mostly in the neck and submandibular body skin scarlet rash and flaking after fading with strawberry tongue isthmus pharyngitis throat swab culture often have group B A streptococcus growth 8.Black fever patients with high fever, liver and spleen lymph node enlargement anemia, leukopenia, bone marrow can be found in the Leishmania microsomes. 9, rodent bite fever by rodent bites to the acute infectious disease pathogen for the small snail bacteria to the patient appeared high fever, localized hard nodular ulcers, local lymph node enlargement with tenderness and skin rash. 10, adenomatous plague lymph node enlargement for the epidemic the first lesions of the inguinal lymph nodes involved in the axillary lymph nodes followed by the cervical lymph nodes often have more serious systemic symptoms lymph node swelling and pain can be softened pus pus found in the pus bacillus of the plague can confirm the diagnosis. 11, rabbit fever is tularemia caused by acute infectious diseases mainly manifested by fever, skin ulcers, local lymph node swelling, a large respiratory symptoms, conjunctival congestion, etc. There is a history of contact with wild rabbits or insect bites to confirm the diagnosis of bacterial isolation and a positive immune response. 12, toxoplasmosis, also known as toxoplasmosis for veterinary and human diseases toxoplasma gondii is a protozoa in the order Sporozoa Coccidioidea and its final hosts are cats and felines birds mammals and humans as an intermediate host human infections associated with the swallowing of undercooked meat or drinking contaminated oocysts of the water related to the condition of the disease varying severity of the confined to the lymph node inflammation is the most common often involved in cervical and axillary lymph nodes of different sizes and without pressure pain is often accompanied by a low-grade fever and other systemic symptoms to confirm diagnosis The diagnosis depends on the pathogen and immunologic tests.