Pregnancy can increase the burden on the liver, and the adrenocorticotropic hormone level of mothers increases during pregnancy, which can lead to high replication of hepatitis B virus and increase the incidence of hepatitis B. Therefore, it is better for mothers-to-be to have a medical checkup in a liver specialist hospital before planning pregnancy. Therefore, it is better for mothers-to-be to have a physical examination in the hospital specializing in liver diseases before they plan to get pregnant, and the physical examination items include liver function, hepatitis B three pairs, HBV-DAN quantification, ultrasound, etc. If there is no abnormality in the liver function and ultrasound, they can plan to get pregnant, but the whole process of pregnancy should be monitored closely on a regular basis for the changes in the liver function and HBV-DNA; if the abnormalities of the liver function are already at the onset of hepatitis B, it is not suitable to get pregnant, but the treatment of hepatitis should be carried out first, and the body will re-enter the immune tolerance period. If the abnormal liver function has been in the hepatitis B morbidity state, then pregnancy is not suitable, but first treat hepatitis, the body re-enters the hepatitis B immune tolerance period before pregnancy. If patients using interferon therapy plan to get pregnant, it is necessary to wait for 6 months after the end of interferon therapy. If pregnancy occurs during the course of interferon therapy, the pregnancy should be terminated and an abortion should be performed in the obstetrics and gynecology department. For mothers-to-be with HBV-DNA quantification ≥105 IU/ml, oral antiviral therapy with nucleoside (acid) analogs (lamivudine, telbivudine, tenofovir) starting at 28 weeks of gestation is recommended to reduce the risk of mother-to-child transmission. There is a rumor that overdue pregnancies (i.e., more than one week past the due date) can result in healthier babies, but this is not true. This is wrong. Overdue pregnancy can cause aging of the placenta and cloudy amniotic fluid, which is not healthy for the baby, and studies have shown that overdue pregnancy can increase the risk of mother-to-child transmission of Hepatitis B. Therefore, it is recommended that overdue pregnancy should be avoided as much as possible in order to minimize the chance of Hepatitis B infection in the uterus. Babies of mothers with hepatitis B virus should be injected with hepatitis B immunoglobulin (HBIG) at a dose of ≥100IU 24 hours after birth (preferably within 12 hours of birth), and at the same time receive hepatitis B vaccine at different sites, and the second and third shots of hepatitis B vaccine at the end of the first and sixth months, which can greatly reduce the rate of mother-to-child transmission. (This is important for mothers-to-be to keep in mind and to insist your supervising OB/GYN to do so, as it is their legal obligation to give your baby the first dose of Hepatitis B vaccine, but usually she will not give your baby Hepatitis B immunoglobulin if you do not explain it to her.) Babies can be breastfed after they have received the Hepatitis B immune globulin and vaccine 12 hours after birth. However, there is still a risk of breastfeeding if the HBV-DNA quantification is ≥105 IU/ml for a mother with triple III. Please stop breastfeeding if: mother’s nipples are cracked and oozing blood, mother’s liver function is abnormal, baby has mouth ulcers. If your baby’s blood is positive for surface antigen (HBsAg) and e antigen (HBeAg) during physical examination, please don’t panic, because HBsAg and HBeAg as well as the related antibodies can pass through the placental barrier and enter the fetus, that is to say, these antibodies are in the mother’s body. 1 year later, if you get 1) Surface antigen HBsAg-positive and anti-HBs-negative, it means that the mother-to-child interruption has failed and the baby is infected with hepatitis B. 2) Surface antigen HBsAg-negative, anti-HBs-positive and anti-HBs＞100mIU/ml, it means that the body has strong protection. 3) Surface antigen HBsAg-negative and anti-HBs-negative, the baby needs to be strengthened with the vaccination.