Existing antiviral drugs can not completely eliminate the hepatitis B virus, the body relies on its own immunity to eliminate the virus is the main force, and antiviral drugs mainly play a role in assisting and promoting, so in order to achieve satisfactory results of antiviral treatment must learn to seize the best time to use antiviral drugs. Hepatitis B virus infection can be divided into four phases: immune tolerance, immune clearance, inactive HBsAg carrier state and hepatitis reactivation. The immune tolerance period is when the body’s immune system coexists peacefully with the hepatitis B virus, does not regard it as a foreign body, and does not launch an attack on it, and the use of antiviral drugs at this time is often a waste of money and energy, and does not achieve good results; what should be done? For hepatitis B virus carriers need to regularly monitor liver function, when transaminases (i.e. ALT and AST) gradually rise, is the body’s immune system began to declare war on the hepatitis B virus, the signal to enter the immune clearance period. It is generally advocated that an increase in alanine aminotransferase (ALT) to between 2x normal and 10x normal is the optimal time for antiviral therapy with interferon without the use of liver-protecting enzyme-lowering drugs. The goal of our anti-disease treatment is: e antigen from positive to negative, e body from negative to positive, i.e., major triple positive to minor triple positive, HBV-DNA drop to the lowest level possible, ALT and AST return to normal, and enter into the inactive HBsAg carrier state. For inactive HBsAg carriers, liver function, HBV-DNA quantification, alpha-fetoprotein (AFP), and ultrasound of the liver and spleen should be rechecked every six months under the long-term supervision of a doctor to determine whether the disease is progressing.