The number of deaf patients in China is huge, about 27.8 million people, accounting for 34% of the total number of people with disabilities as a whole. Deafness brings great pain and heavy economic burden to patients and families. A significant number of these patients are deaf due to the inadvertent use of ototoxic drugs. In my clinic, I often see patients, including many adolescents, who have become deaf due to the use of ototoxic drugs, which makes people sigh with sorrow. It is our duty to remind everyone of the dangers of ototoxic drugs, and we would like to emphasize the issue of ototoxic drugs again with our friends. Ototoxic drugs are a class of drugs whose toxic side effects can cause symptoms such as vertigo, tinnitus and deafness after use. In sensitive cases, one injection can even cause deafness! There are nearly 100 known ototoxic drugs, and they are commonly used as follows: 1. Aminoglycoside antibiotics (streptomycin, butamycin, neomycin, gentamicin, cotrimoxazole, acamycin, etc.), which are the most common ototoxic drugs in clinical practice; 2. Macrolide antibiotics (erythromycin, etc.); 3. Anticancer drugs (vincristine, 2-nitroimidazole, cisplatin 4. salicylic acid analgesics (aspirin, etc.); 5. antimalarials (quinine, chloroquine, etc.); 6. tabular diuretics (tachyphylaxis, diuretic acid); 7. anti-heparinization agents (Paulanbrain); 8. thalliumide agents (reaction stop), etc.