Chronic mental stress such as excessive work pressure, constant psychological tension, and irritability stimulate the pituitary-adrenal axis, causing an increase in adrenal-derived androgen secretion. Androgens can increase the hypertrophy of sebaceous glands and increase the production of sebum; at the same time, they also cause hyperkeratosis of hair follicle ducts and blockage of pores, resulting in poor sebum excretion and accumulation of sebum, which can cause acne to break out or worsen or persist. When people are angry, the sebaceous glands secrete too much, and when they are remorseful, the sebaceous glands are occluded, leading to increased opportunities for bacterial infection in the hair follicles, causing varying degrees of inflammation around the hair follicles to form acne.