Chen Yihang, a 10-month-old baby from Bengzhou Village, Xike Town, Tongan District, Xiamen, Fujian, was found to have biliary obstruction with yellow sclera and white stools half a month after birth. However, three months later, the child’s skin and sclera became yellow again and showed a tendency of progressive aggravation, the color of stool also became white again, the abdominal circumference gradually increased, and all indicators of liver function continued to deteriorate. The only way to save the child’s life is to perform a liver transplant. The most timely and effective treatment is the living liver transplantation with partial liver donation from relatives within three generations, and the matching of blood types is the first and most important part of the matching process. The main pathological manifestation of AMR is diffuse intravascular coagulation (DIC) in a single organ of the liver, and the key factor affecting the development of AMR is the titer of anti-ABO antibodies in the perioperative period, therefore ABO In order to eliminate or reduce pre-operative anti-ABO antibodies, plasma exchange, splenectomy and rituximab to block B-cell function, intraoperative indwelling portal vein or hepatic artery local injection devices, and postoperative local injection of methylprednisolone, prostaglandin E1, and methanesulfonic acid through portal vein or hepatic artery ducts have emerged successively. Since infants less than 1 year old often have not yet fully established humoral immunity and the titers of ABO antibodies are very low, the above measures are often not necessary in the perioperative period when performing ABO blood group incompatible parental liver transplantation on infants. On July 25, 2013, a pediatric liver transplantation team led by Xia Qiang and Zhang Jianjun, directors of our liver surgery department, performed a living liver transplantation on Chen Yihang, whose mother provided the left outer lobe of his liver, after the preoperative preparations were completed. Little Yihang’s total bilirubin dropped to the normal range 1 week after surgery, the child became whiter and smiling, and he was discharged from the hospital 18 days after surgery. The success of the operation means that more children with end-stage liver disease waiting for liver transplantation will not lose the opportunity of parental transplantation due to incompatible blood types of the donor-recipient, and for children with end-stage liver disease, as long as For children with end-stage liver disease, ABO incompatible parental liver transplantation is also a timely, effective and safe treatment as long as a scientific and effective perioperative immunosuppression management program is in place.