Minimal liver cancer refers to liver cancer with a tumor diameter of <2cm, and small liver cancer refers to liver cancer with a tumor diameter of 2 to 5cm. After years of evolution of various clinical treatment modalities, its treatment has evolved from "single surgical resection" to "combination of surgical resection, local treatment and liver transplantation". Which treatment modality is the most preferable and the best? First of all, it can be affirmed that surgical resection is still an important part of the treatment of small liver cancer and micro liver cancer in the 21st century, and it is an important way to obtain long-term survival, according to statistics, the 5-year survival rate of small liver cancer after surgical resection is over 50%. The chance of liver failure increases after excision is too large, therefore, at present, local resection instead of lobectomy not only improves the resection rate, but also reduces the surgical mortality rate, while there is no significant difference in survival rate. Small hepatocellular carcinoma and microhepatocellular carcinoma are hepatocellular carcinomas that meet the international Milan standard. After liver transplantation, such patients can achieve similar results as benign diseases, and the 5-year survival rate can reach about 80%, which is significantly higher than that of local resection. Why is the effect of liver transplantation significantly better than local resection? There are several reasons: 1. After local resection, some cancer cells may remain, and these cancer cells may recur at any time, which can be called "the fire of a star can start a prairie fire"; whereas liver transplantation is to remove the whole diseased liver, which eliminates the possible residue to the greatest extent, thus effectively improving the long-term survival rate. 2. The occurrence of liver cancer is closely related to hepatitis B virus, and the three-step process of "hepatitis→cirrhosis→hepatocellular carcinoma" is very clear. This can also be called as "fertile land helps to grow 'coward'"; while liver transplantation not only removes the diseased liver based on the original hepatitis B, but also can be done for hepatitis B. Most patients can turn negative after liver transplantation. 3. Liver cancer has the biological characteristic of intrahepatic metastasis, and local resection cannot eliminate potential intrahepatic metastatic lesions, which can continue to grow and expand, which can also be called "metastasis of base"; liver transplantation removes all diseased livers and completely eliminates potential metastasis, thus eliminating the potential base of liver cancer cells. The liver transplantation completely eliminates the potential metastasis, thus eliminating the potential base of liver cancer cells. For these reasons, liver transplantation is superior to local resection in the long term when conditions permit. Since liver transplantation is better than local resection, why do some patients not choose liver transplantation? There are several reasons: 1. Perception: The perception of many patients and their families has not yet recognized that liver transplantation is currently a very mature procedure and generally safe, and many people cannot accept this treatment. 2, funding: most local excision costs around 30,000 yuan can be, while most liver transplantation treatment requires about 400,000 yuan, the huge medical costs make many patients can not choose this treatment. 3, timing: local excision can be scheduled by the doctor for surgery, while liver transplantation requires waiting for a liver source, and liver transplantation is not possible without a donor liver, and the increase in the number of patients waiting for transplantation and the shortage of liver sources are becoming more and more prominent, many patients choose local excision because they are afraid of the development of the disease during the waiting process.