Patient, male, 46 years old, from Anfeng Town, Dongtai City, Jiangsu Province. He has been engaged in small department store business for 6 years. Since March 2004, he started to have lower abdominal pain, and then sought medical treatment in several hospitals in Yancheng City and Shanghai. Gastroscopy suggested erosive esophagitis, and abdominal ultrasound and CT examination were normal. Two weeks later, the pain worsened and abdominal cramps developed. He was hospitalized in a local hospital and was diagnosed with acute appendicitis and treated surgically. However, postoperative abdominal pain was still present. There was no significant change in the nature and degree of abdominal pain compared with that before surgery. He ate normally, worked and lived normally, and occasionally had constipation. Once when he was persuaded by his friends to drink at a friend’s party, he leaked out the hidden truth. One of his friends (a native of Pujiang, Zhejiang Province, also a businessman, also treated in our hospital for abdominal pain) immediately advised him to come to our hospital for medical treatment after learning about his condition. The patient was admitted to the hospital with “lower abdominal pain for more than half a year”. The patient had pain around the umbilicus with no obvious cause six months ago, which was dull and tolerable. At that time, there was no acid reflux, no nausea and vomiting, no diarrhea and black stool, normal stool frequency, no painful blood in stool and no foreign body prolapse. There was generalized weakness, no chills and fever, no abnormal sensation in both upper limbs, no restriction of activity, no limb tremors. There was no dizziness and palpitation, no cough and sputum, no chest pain and hemoptysis, and no petechiae on the skin of the whole body. He was seen at the local hospital and several hospitals in Shanghai, and abdominal ultrasound and CT examination were normal, and no cause of abdominal pain was found. After receiving symptomatic supportive treatment (details not available), the abdominal pain symptoms did not improve significantly. The abdominal pain was aggravated by colic with nausea and vomiting at the onset of the disease for half a month. The vomit was stomach contents without coffee-like substance. In a hospital in Yancheng City, he was diagnosed with “acute appendicitis” and underwent surgery. He was discharged 13 days after the surgery. However, the abdominal pain never stopped after the operation, mostly mild dull pain, which was tolerable, mainly around the umbilicus, and eating was not affected. He was introduced by a friend to our hospital for further treatment and was admitted to our department. The patient was clear, in general spirits, poor appetite, still sleeping peacefully at night, no insomnia, no excessive dreaming, no difference in stool, no sudden change in weight. In April 2004, he underwent local appendectomy, and in 2008, gastroscopy showed erosive esophagitis (specific medication is not known). He denied history of hypertension, diabetes mellitus and food and drug allergy. No special. Personal history: born, raised and worked in the place of origin, denies history of exposure to epidemic water and epidemic areas. History of smoking for 10 years, 10 cigarettes/day, now quit, drink a small amount of alcohol; deny history of smuggling. Marriage and childbearing history: Married at an appropriate age, with one child, spouse and daughter are healthy. Family history: mother is alive, father died of lung cancer, sister died of lymphoma, brother and brother are healthy; deny history of major family genetic diseases in the second and third generations. On admission: T36.8℃, R20 times/minute, P80 times/minute, BP100/60mmHg, clear, mental and general nutrition. He was admitted to the ward, in an autonomous position, and was cooperative in physical examination and answering tangential questions. The whole body skin and mucous membrane did not show yellow staining, and the superficial lymph nodes were not enlarged. The cranium was normal in size, with no deformity. The pupils were equally large and rounded bilaterally, and the reflex to light was present. The external auditory canal was unobstructed, with no pulling pain, no bilateral mastoid pain, and normal hearing. The nasal passages were clear, with no abnormal secretions and no pressure pain in the paranasal sinuses. The mouth and lips were not cyanotic, the oral mucosa was intact and not broken, the tonsils were not enlarged bilaterally, the teeth were not loose or lost, and no lead lines were seen on the gingival margin. The neck was soft, the trachea was centered, the jugular vein was not angry, the thorax was symmetrical bilaterally, there was no deformity, and the respiratory movements of both lungs were symmetrical bilaterally. Tactile fibrillation was symmetrical bilaterally, and percussion was clear. The respiratory sounds of both lungs were clear, no dry and wet rales were heard, the heart turbid boundary was not enlarged, the heart rate was 80 beats/min, the rhythm was uniform, and no obvious pathological murmurs were heard in the heart valve areas. The abdomen was soft, with light pressure pain around the umbilicus, and the liver and spleen were not detected under the ribs. Mobile turbid sounds were negative, and percussion pain in the liver and kidney area was positive. Bowel sounds were normal. No swelling of both lower limbs. The muscle strength and muscle tone of the limbs were normal, knee reflex was present, Achilles tendon reflex was present, and no pathological signs were elicited. General ancillary tests: blood erythrocytes 5.8 10*9/L, neutrophil ratio 52.15%, hemoglobin 152g/L, lymphocytes 209 10*9/L. Urine routine showed occult blood +1 25 cel/μL, erythrocytes +-/HP, leukocytes U2 2-3/HP; stool routine showed no difference. Electrocardiogram showed sinus bradycardia. Abdominal ultrasound showed multiple polyps of gallbladder and cholecystitis. Flat X-ray of abdomen showed no significant abnormality. And about gastroscopy, capsule endoscopy, abdominal CT examination. Of course the subsequent examination results were normal. Especially, capsule endoscopy could examine the whole gastrointestinal tract and no abnormality of gastrointestinal tract was found. It means that the abdominal pain is not intestinal inflammation, foreign body, tumor and other diseases When pursuing the patient’s work and living habits, the patient confided that usually when the business is not busy, he uses the meditation paper folded into the shape of a golden dollar to buy (to increase the added value of meditation paper). When it comes to the paper, I subconsciously asked, “Is it the golden yellow or silver white kind?” He replied that it was, and that it was imported from our Zhejiang Province. The patient was exposed to lead and had a history of working with lead, so I suspected that the patient might have chronic lead poisoning. I suspected that the patient might be suffering from chronic lead poisoning, so I immediately gave him a lead repellent test. The following day, we checked the urinary lead and the indicators of lead-induced enzyme damage in human body, namely, δ-amino α-ketopentanoic acid and fecal porphyrin. The result of urine lead value was 0.352mg/L. This value should be diagnosed as “lead poisoning observation subject” for a lead worker. For ordinary patients who have symptoms such as abdominal pain and constipation, chronic mild lead poisoning is considered. After the diagnosis was clear, the treatment was easy to solve, and the symptoms were relieved and improved after three courses of lead expulsion treatment were given successively. Later, there was no more abdominal pain.