Many gallbladder stone patients are hesitant to have surgery for fear that gallbladder removal will affect their bodies, or they blindly hope to have gallbladder preservation surgery. In fact, gallbladder removal has very little effect on the body. The gallbladder mainly serves to store and concentrate bile, which is drained after eating to help digest fat. Gallbladder removal has minimal impact on the body, and most of its bile storage function can be compensated by the bile ducts. The current literature reports that approximately 2-17% of patients will have diarrhea after cholecystectomy, but it is generally believed that the percentage is no more than 5%, and the exact cause is unknown and may be related to a disturbance in the neurohumoral regulatory system. Many of these diarrheas are similar to irritable bowel syndrome, which is characterized by paroxysmal abdominal pain within half an hour after eating, followed by loose stools, and the abdominal pain disappears after defecation, which can occur several times a day. However, this type of diarrhea is mostly self-limiting and can resolve on its own after one to several months, and in most patients it gradually disappears after six months to several years. There are no particularly effective drugs available for targeted treatment. Therefore, even if diarrhea occurs, patients do not need to be overly stressed, as it usually heals on its own, and it is extremely rare for it to be so severe that it affects work life and requires medical intervention.