The timing of cranial repair surgery is the most common question asked by patients with traumatic brain injury skull defects. In general, cranial bone repair surgery should be performed 3-6 months after open debridement. For closed craniocerebral trauma with a well-healed incision, cranial bone repair surgery can be performed 3-4 months after surgery. For patients with open craniocerebral trauma, the risk of postoperative infection is higher, and cranial repair surgery is usually chosen to be performed 4-6 months after surgery. Of course, the specific timing of the operation should be selected according to the patient’s specific situation, so patients should be regularly reviewed after the craniotomy, so that doctors can grasp the patient’s condition changes, in order to determine the appropriate time for surgery. As for the early cranial repair surgery recommended by some hospital doctors, which refers to cranial repair surgery within 2 months or even 1 month after craniotomy, I personally think that it is not suitable to promote it for the time being, as there are still big differences in opinions about it, and several recent international studies do not recommend early cranial repair surgery (<2 months).