Back in 1992, the World Health Organization issued the famous “Victoria Declaration” at the International Conference on Heart Health held in Victoria, Canada. The declaration proposed to build a golden bridge between scientific arguments and the public, and the four cornerstones of this bridge are: reasonable diet, moderate exercise, smoking cessation and alcohol restriction, and psychological balance.” Among them, the word “alcohol restriction” is really evocative. From that time onwards, the statement that moderate drinking is good for health became folklore. I have witnessed a friend from the original very little alcohol, to later a few glasses a day, said “softening blood vessels, to prevent stroke”, I think this is purely a monk chanting a distorted view and behavior, really do not agree. By 2002, the World Health Organization released a cancer surveillance report, pointing out that “we should pay attention to diet and the role of alcohol in carcinogenesis”, and reminded people that “alcohol” may cause cancer, and only low quality wine, such as wine, can reduce the risk of cardiovascular disease and is good for health. Only low quality wine, such as wine, can reduce the risk of cardiovascular disease and is good for health; but excessive drinking, especially alcoholism, can lead to alcoholism, which can seriously damage health and induce cancer. This is somewhat disorienting. The correct view of alcohol and alcohol consumption is a scientific and social issue, but also a matter of human behavior. Similar to smoking, drinking large quantities of alcohol over a long period of time is addictive, and once addicted, the act of drinking itself is difficult to reverse, and the damage to the body is difficult to correct. The problem of inducing cancer among them becomes very prominent. So alcoholism or alcohol addiction must be a self-inflicted behavior. The damage of alcohol on the human body should be discussed in terms of “quantity” and “quality” respectively. Nothing has been studied more fully than alcoholic liver disease, including liver cancer, because the main component of alcohol, ethanol, needs to be metabolized in the liver, and different individuals have different strengths and weaknesses in the liver’s ability to metabolize ethanol, so even if the same amount of alcohol is consumed, the consequences can be significantly different. Domestic authoritative textbooks or authoritative experts are more consistent: a history of long-term drinking, generally more than 5 years, according to the amount of ethanol (one or two high white wine about 25 grams of ethanol), in men greater than or equal to 40 grams per day, women greater than or equal to 20 grams per day; or a history of heavy drinking within 2 weeks, equivalent to the amount of ethanol greater than 80 grams per day. The diagnosis of alcoholic liver disease is established when liver damage occurs under such circumstances and other causes of liver disease are excluded. The most serious form of alcoholic liver disease is “alcoholic cirrhosis combined with liver cancer”. In Western countries, liver cancer caused by alcoholism accounts for the first place of primary liver cancer, while in China, due to the high incidence of hepatitis B, alcoholic liver cancer is still in the second place, but with the effective control of hepatitis B, the proportion and absolute value of primary liver cancer caused by alcohol are on the rise year by year. More importantly, if patients with chronic viral hepatitis abuse alcohol, the incidence of cirrhosis and liver cancer within 5-10 years is ten times higher than that of non-alcoholics. I have done a rough count of patients with chronic hepatitis B and found that in several pairs of brothers with chronic hepatitis B, the alcoholic often died of cirrhosis and liver cancer before the age of 55, while the brother who survived and received further treatment was often the one who did not drink. It can be seen that patients with viral hepatitis, if also addicted to alcohol, it can be worse for the liver, is extremely irresponsible behavior for their health and life. In the early years, one of our scholars studied the effect of a famous domestic spirits on the liver of animals and came to the conclusion that the spirits do not easily cause liver damage and do not cause cirrhosis of the liver, which has led to extensive debate in the academic community. In fact, there is an important description that the researcher did not draw the attention of his colleagues: his conclusion was based on the use of commercially available poor quality liquor as a control group, and the result was a “comparative” study. This suggests to us that it is important to control not only the dose of alcohol but also the quality of alcohol. Alcoholic beverages not only produce ethanol in the fermentation or distillation process, but also polycyclic aromatic hydrocarbons, including benzo(a)pyrene and benzanthracene, and may even be mixed with chemicals such as asbestos, which are very strong carcinogens. Poor quality alcoholic beverages also contain more formaldehyde. Formaldehyde, like acetaldehyde, a metabolite of ethanol, is a molecular cross-linking agent that can promote the aging of polymeric substances in vitro and inevitably promote the aging of living substances in vivo, thus also being an important factor in promoting carcinogenesis. In addition, research has confirmed that: 1. alcohol can dissolve many carcinogenic substances, making it easy to break through the protective barrier of human mucous membrane and be more easily absorbed by tissues to cause cancer. Alcohol can also induce the activity of certain enzymes in the body, such as polycyclic aromatic hydrocarbon activating enzymes and benzo(a)pyrene hydroxylase, etc. The enhanced activity of these enzymes accelerates the production or activity of such carcinogenic substances, thus advancing the process of carcinogenesis. Of course, alcohol (ethanol) itself can also promote cell mutation, which is one of the important reasons why alcoholics are prone to cancer. In addition to the aforementioned liver cancer, it is no exaggeration to say that where alcohol goes, it has the potential to sweep away all the normal tissue cells it touches, for example, alcohol can cause oral mucosa cancer and throat cancer, with the incidence of throat cancer 10 times higher in alcoholics than in non-drinkers! The incidence of esophageal cancer is 20 times higher in alcoholics than in non-alcoholics! Stomach and colon cancers are also associated with long-term and heavy alcohol consumption. Regardless of the arguments from that perspective, alcoholism must be an extremely bad habit, and we do not need to sip old wine every day in order to so-called soften blood vessels, prevent cardiovascular diseases, or even to prolong life. For people with basic liver disease, drinking not only hurts the liver, but also because the liver’s detoxification and metabolic functions have been reduced, drinking alcohol is more likely to cause alcohol-induced lesions in other organs, including the development of cancer. Let’s, or do not drink it!