Burning sensation in the chest and back can be caused by a variety of reasons, which are commonly found in digestive system diseases, cardiovascular system diseases, chest diseases, and so on. 1. Digestive system diseases: reflux esophagitis, gastritis, gastric ulcer, esophageal cancer may cause burning sensation in the chest and back. Esophagoscopy and gastroscopy can help in diagnosis. 2. Cardiovascular system: angina pectoris, coronary heart disease and myocardial infarction may cause the above symptoms, and myocardial damage marker test and coronary angiography may be needed to help diagnose. 3. Chest diseases: chest tumor, internal chest infection, pleural inflammation, pleural effusion, tuberculosis and so on may have the above symptoms, chest CT, blood inflammation index and other tests can help to diagnose. There may be other reasons for the burning sensation at the back of the chest, and it is recommended to consult a doctor in time to clarify the cause of the disease and standardize the treatment under the doctor’s guidance, so as to avoid delaying the condition.