The onset of liver cancer is relatively insidious and there is usually no symptom in the early stage. When patients show obvious clinical symptoms, the condition is often in the middle and late stage. The first symptom of hepatocellular carcinoma is pain in the liver area, followed by upper abdominal mass. Some patients also show some complications of cirrhosis, such as black stool, vomiting blood, jaundice, liver coma, ascites, etc. A few patients are admitted to hospital due to symptoms caused by metastases. 1. Pain in liver area The vast majority of patients with middle and late stage hepatocellular carcinoma have pain in liver area as the first symptom, and the incidence rate is more than 50％. The pain in the liver area is usually located in the right rib area or under the saber process, and the nature of pain is intermittent or continuous hidden pain. The pain is intermittent or persistent, dull or stabbing, and the patient may feel discomfort in the right upper abdomen for some time before the pain. The pain may be mild and severe or may be relieved by itself for a short period of time. The pain is mainly caused by the rapid enlargement of the tumor, which compresses the peritoneum of the liver and produces pulling pain. In a few patients, the sudden onset of severe pain in the liver area spontaneously or after liver puncture is mostly due to the rupture and bleeding of cancer nodules located on the surface of the liver. If there are also signs of blood pressure drop and shock, and bloody fluid in the abdominal cavity, it means that the rupture and bleeding of cancer nodules are serious. In this case, emergency resuscitation is needed. If there is no such accompanying symptom and the pain is more limited, it indicates that the bleeding is located under the liver peritoneum. 2.Gastrointestinal symptoms Decreased appetite, epigastric fullness after meals. Ambiguous gas, indigestion and nausea are common digestive tract symptoms of liver cancer, among which loss of appetite and abdominal distension are the most common. Diarrhea is also a common digestive tract symptom of hepatocellular carcinoma, which can be easily mistaken for chronic enteritis. Portal hypertension and intestinal dysfunction caused by portal vein or hepatic vein cancer thrombus can lead to abdominal distension and increased stool frequency. Gastrointestinal dysfunction can also lead to indigestion, ambiguous gas, nausea and other symptoms. 3.Fever A considerable number of liver cancer patients will have sweating and fever. Most of the fever is low to moderate fever, and a few patients may have high fever, above 39℃, which is usually not accompanied by chills. Most of the fever in liver cancer is cancer fever, which is caused by the release of pyrogen into the blood circulation after the necrosis of tumor tissue. It is sometimes not easy to distinguish it from cancer fever of liver cancer, which can only be determined by combining with blood picture and observing the effectiveness of antibacterial treatment. 4. Lethargy and fatigue Patients with liver cancer often feel more fatigue than patients with other tumors, similar to patients with chronic hepatitis. The causes of weakness and emaciation are unknown, and may be due to digestive disorders, lack of energy due to impaired nutrient absorption, or long-term consumption of tumor. With the development of the disease, the degree of wasting can be aggravated, and in serious cases, cachexia may appear. 5.Lower limb edema Patients with hepatocellular carcinoma with ascites often have lower limb edema, which may occur in the ankle in mild cases or spread to the whole lower limb in severe cases. The main reason for lower limb edema is that ascites compresses lower limb veins or cancer embolism obstructs the venous return. Mild edema can also be caused by low plasma albumin. 6. Bleeding tendency Patients with hepatocellular carcinoma often have bleeding tendency such as gum bleeding and subcutaneous bruises, which are mainly due to impaired liver function and abnormal coagulation function, especially in patients with liver cancer combined with cirrhosis. Gastrointestinal bleeding is more common, mainly due to varices of esophagogastric fundus vein caused by portal hypertension.