Gallstones are a common disease with an incidence of about 15% in our population. Medical research has found that the onset of gallstones is related to many factors such as physical condition, diet and disease, so who are vulnerable to gallstones? Obese people The incidence of gallstones is 5 times higher than normal for those who weigh more than 15% of the normal standard, and the incidence of gallstones is 6 times higher for obese women aged 20 to 30 than for their normal weight counterparts, and 40% of obese women over 60 have gallbladder disease and gallstones. The reason is that most obese people have too much fat and cholesterol intake, coupled with the fact that most obese people are less active and prone to gallstones. Those who eat meat, sweet or don’t eat breakfast. Those who eat meat and sweet will have more fat and cholesterol intake, which is easy to form cholesterol stones; too much sweet food and promote insulin secretion, which will accelerate cholesterol deposition; often do not eat breakfast will reduce the content of bile acid, bile concentration, which is conducive to stone formation. In women, 70% of gallstones patients are women, and the more pregnancies there are, the higher the incidence. The reason is that the high level of estrogen in women affects the formation of glucuronide bilirubin in the liver and increases non-conjugated bilirubin; estrogen also affects the emptying of the gallbladder and causes bile stagnation, which makes it very easy to form stones. The incidence of gallstones increases in postmenopausal estrogen users. Too little exercise will affect the function of the digestive system, resulting in reduced gallbladder function, and bile will be easily stagnant and difficult to excrete; it will also prevent the reabsorption of bile acids, resulting in easy deposition of cholesterol into stones. The incidence of gallstones in patients with cirrhosis is significantly higher than that of normal people, which is related to the reduced inactivation of estrogen and higher estrogen levels in patients with cirrhosis, as well as chronic hemolysis, low gallbladder contraction, poor emptying of the gallbladder, biliary varices, and elevated bilirubin in the blood. People who are exposed to too much sunlight, such as farmers and sunbathers, are prone to gallstones. Frequent sunbathers have a higher prevalence of gallstones, and those who have been burned by sun exposure have the highest prevalence of gallstones. In addition, epidemiological findings suggest that genetic factors may also contribute to the occurrence of gallstones. Immediate family members such as parents, siblings or children with gallstones are at high risk of developing the disease.