Chemotherapy and targeted therapy were ineffective, and Chinese medicine was used to extend the survival of patients with advanced lung cancer Case 1: Female patient, 60 years old, with no obvious cause of coughing and sputum in March 2008, which was white and sticky without coughing up blood. After three cycles of chemotherapy with GC regimen, the efficacy was evaluated as progressive, followed by one cycle of chemotherapy with Tysodex + cisplatin second-line regimen, which was not tolerated due to gastrointestinal reactions, and then changed to three cycles of chemotherapy with single agent Tysodex, the efficacy was evaluated as progressive, followed by one month of oral ERSA, but the symptoms did not improve. The patient visited Xuanwu Hospital twice on September 16, 2008 and October 13, 2008 for two cycles of chemotherapy with Lipitor + Carboplatin regimen, the efficacy evaluation was PD, CEA 90.16ng/ml, and no significant symptom relief. On January 19, 2009, he was first admitted to our hospital: chest CT showed an irregular soft tissue mass around the bronchus in the basal segment of the right lower lobe, measuring approximately 32 mm × 28 mm, with irregular lobulated margins and visible burrs; multiple small dot-like and nodule-like high-density shadows with unclear borders were seen in the right upper lung, and no clear abnormal density was seen in the rest of the lung lobes. The mediastinum was not displaced, and multiple enlarged lymph nodes were seen in it. The right hilar shadow was enlarged, and no abnormality was seen in the left hilar. No pleural fluid or pericardial effusion was seen. The right axilla and supraclavicular region showed nodular shadow. Bone scan showed abnormal bone metabolism in the right humeral head and the middle and upper part of the right humerus, and bone metastasis was considered. The diagnosis was: right lung cancer with lymph node metastasis and bone metastasis in the right lung and mediastinum, right axilla and supraclavicular region, stage IV. Considering that the patient had already undergone multiple courses of chemotherapy and targeted therapy in the past and the treatment was ineffective, this treatment was decided to adopt an individualized treatment plan based on Chinese medicine treatment, combining evidence-based Chinese medicine + anti-cancer Chinese medicine injection, and combining evidence-based and disease-based treatment. The patient’s symptoms include coughing and sputum with little sputum and white color, easily coughing up, weakness, sweating at times, lumbar ache, nausea, difficulty in sleeping at night, and diaphoresis. The tongue is light and dark, the tongue coating: thin and white, and the pulse: thin and weak. The formula is as follows: Chen Pi 10g, Qing Han Xia 10g, Loquat Leaf 12g, Almond 9g, Fried Citrus Aurantium 10g, Golden Buckwheat 18g, Shi Jian Dian 15g, Prince Ginseng 18g, Raw Astragalus 30g, Fang Feng 9g, Tao Ren 10g, Safflower 6g, Raw Malt 30g, Shen Qu 15g. The patient was discharged from the hospital with cough and sputum symptoms reduced. From then to November 2009, the patient came to our hospital every 2-3 months for one cycle of inpatient treatment, using the individualized treatment plan of Chinese medicine consisting of evidence-based traditional Chinese medicine and Aidi injection. During the discharge period, he visited our outpatient clinic every two weeks to adjust his Chinese medicine prescription, and his condition improved significantly. In the second hospitalization on May 5, 2009, the CEA was 30.16ng/ml and the size of the mass in the right lower hilar region was significantly smaller than before, about 14mm×23mm, compared to the CT chest film on 09-01-20. The lymph node shadow in the right axilla, supraclavicular region and mediastinum was significantly better than before. The left humeral head had a limited hypodensity area, which was not significantly changed from before. On August 12, 2009, he was hospitalized for the third time, and the CEA 4.68ng/ml was reexamined, and the CT chest lesion was further reduced. Compared with the 09-01-20 film, the size of the mass in the right lower hilar region was about 13×20 mm; the degree of involvement of the adjacent bronchial tube wall was less than before; a small amount of faint ground glass-like shadow in the right upper lung was approximately the same as before. The lymph node shadow in the right axilla, supraclavicular region and mediastinum was slightly reduced compared with the previous one. The left humeral head had a limited hypodense area, which was not significantly changed from before. From November 2009 to January 2010, the patient stopped using traditional Chinese medicine due to the stabilization of the lesion, and the cough and sputum appeared again after a trip to Hainan with a cold and exertion. On January 13, 2010, he was hospitalized for the fifth time: CEA 17.31ng/ml was rechecked, and chest CT showed that “the mass in the right lower hilar region is larger than the previous film, and now the size is about 28×26mm, and the irregular thickening of the right middle and lower lobe bronchovascular bundles is more obvious than before. He was admitted with cough, no sputum, occasional nausea, no vomiting, pain in the right axilla and right chest, dry mouth, fatigue, poor appetite, sleep, stool regulation, tongue texture: light and dark, tongue coating: little coating, pulse: weak. At the same time, considering the recurrence of the patient’s disease, the treatment plan was adjusted and the patient was treated with anti-cancer injection and discharged with one cycle of treatment, and the cough and sputum improved. Comment: This patient has advanced lung cancer and has used the first-line chemotherapy regimen carboplatin+Kenzyme and the second-line regimen cisplatin+Tysodi, both of which were evaluated as progressive. became an important choice. The combination of evidence-based and disease-specific treatment and individualized treatment are the basic principles for the development of individualized TCM tumor treatment plan. In this case, the patient was firstly treated with TCM based on the clinical symptoms, tongue and pulse, and secondly, the patient was diagnosed with the pathology and started to treat the disease. The patient had deficiency of qi and blood after multiple courses of chemotherapy, the tumor was increasing in size, and the poisonous evil was contained within, so the treatment should focus on both helping the righteous and eliminating the evil, and benefiting the qi and replenishing the blood as well as detoxifying and anti-cancer. We adopted Addy injection as the main treatment drug for identifying the disease. This injection is composed of Astragalus, Acanthopanax, Ginseng and Zanthoxylum. Basic experiments found that its active ingredients are mainly ginsenoside, astragalus polysaccharide, acanthopanax polysaccharide and desmethylparaben, which can induce apoptosis of tumor cells, inhibit their proliferation and improve human immunity. Previous clinical reports have shown that this injection with chemotherapy can significantly improve the tumor control rate of non-small cell lung cancer patients, among which the control rate of lung adenocarcinoma is better than that of lung squamous carcinoma. Combined with the above studies, we selected Addy injection for the discriminatory treatment. From January to October 2009, the combination of discriminative herbal medicine + anti-cancer injection was effective as the patient’s symptoms such as cough and sputum disappeared, the tumor marker gradually decreased from 90.36ng/ml to 4.68ng/ml, and the mass in the lung also shrank significantly. Although the tumor increased again after 2 months due to the discontinuation of discriminative Chinese medicine, the overall survival has reached 24 months, and the survival of Chinese medicine individualized treatment after the failure of western medicine has reached 15 months. Patients with advanced non-small cell lung cancer have a poor prognosis, with an overall survival of 5-6 months, a 1-year survival rate of 20%-25%, and conventional chemotherapy prolonged by 2-3 months, so the treatment of this patient is still very effective, and from this case Therefore, the treatment of this patient is still very effective, and from this case, we also feel the potential role of individualized treatment of Chinese medicine in the treatment of advanced lung cancer.