Mobius syndrome (also known as congenital oculofacial palsy) is a common form of congenital facial palsy that causes untold suffering to both the child and the entire family. Clinical manifestations: Mobius syndrome is mainly characterized by dysfunction of both facial nerve and eye movement. The facial palsy is characterized by bilateral facial palsy, shallowing of the nasolabial folds, inability to raise the forehead, eyebrows and cheeks, and a pseudomask face. Eye disorders: the eyes are in the inward position, the vertical movements of both eyes are normal, and the spokes are normal. Mobius syndrome is often associated with other congenital anomalies. Such as cranial nerve dysfunction (motoneurology, trigeminal, glossopharyngeal, vagus, parasympathetic and hypoglossal nerves); malformations of the five senses; skeletal muscle deformities of the extremities; cognitive impairment, etc. Etiology: The etiology of the disease is unknown and is presumed to be related to genetics, intrauterine infection, radiation, and poisoning. Treatment: Surgery is the only treatment. Surgical aim: To restore facial motor function and reconstruct expression through neuromuscular transplantation (vascularized thin femoral muscle transplantation).