Usually, there is basically no significant difference in the symptoms of hepatitis B in women compared to men, except for the reproductive symptoms. In women with hepatitis B, the decrease in estrogen inactivation and increase in estrogen in the body due to decreased liver function may lead to reproductive symptoms such as menstrual disorders, amenorrhea, and decreased libido. In addition, for general conditions, patients may have symptoms such as aversion to grease, vomiting, and abdominal distension because of abnormal liver function and reduced bile secretion; patients have impaired bilirubin utilization and excretion and increased bilirubin concentration in the blood, which causes yellow color of urine as well as yellow staining of eyes and skin; some patients may also have symptoms of discomfort or pain in the liver area. Patients may also experience fatigue, fatigue, fever, and poor sleep. As the disease slowly develops, patients may also develop liver palms, i.e., the palms of the hands are congested with blood in the shape of flakes between the large and small fissures, and become white when pressed; they may also develop spider nevi, which are clusters of capillaries shaped like spiders on the skin that disappear when pressed; they may also develop a liver disease face, with a dark, dull, lusterless face and rough, dry skin. When the disease of hepatitis B progresses to a later stage, due to changes in liver tissue, patients often develop cirrhosis and portal hypertension, which may cause symptoms such as splenomegaly and gastrointestinal bleeding.