(a) often stay up late easily lead to infertility infertility patients are often concentrated between 18 to 45 years old, have a common point: no special disease in the past, the body organs are well developed, usually feel tired other than no discomfort. However, work pressure is high, requiring frequent overtime work or late nights, irregular life or poor sexual function, short ejaculation time. Poor sperm quality. According to a research report, “a person in a long-term fatigue, men stay up late for a long time, so that the body hypothalamus, pituitary endocrine hormone levels disorder, endocrine disorders. Androgen is low, estrogen is elevated, it will cause sperm production disorders, resulting in less, weak, teratozoospermia, and as a result, male infertility.” (B) chronic fatigue triggered by physical dysfunction if men are in a long-term over-fatigue, stressful state, can lead to chronic fatigue, and the harm continues to accumulate and deepen, gradually by the occasional physical dysfunction into a regular. Sexual and reproductive functions are only the more sensitive and fragile systems of the body’s major organ systems, which manifest themselves earlier in the problem. The other organs and systems in the night with the increase, over time, the male physiological system can cause pathological damage, causing organic changes, eventually leading to “impotence”, “premature ejaculation” occurrence, and even lead to an increased risk of sudden death. (C) long-term stay up late will hurt the eyes Stay up late on the eyes of the damage is not just a “panda eyes” so simple. The long time overload eye, will make the eyes appear pain, dryness and other problems, and even make people suffer from dry eye disease. In addition, the excessive strain caused by staying up late for a long time may also induce central retinitis, leading to a sudden drop in vision. Remedial measures: stay up late with more eyes, it is best to rest every hour for about 15 minutes, you can choose to look away, do eye exercises and other ways. (d) Long-term staying up late will significantly reduce a person’s immunity, and as a result of long-term accumulation, the probability of the human body suffering from various tumors will increase significantly.