The occupancy of the tumor and peritumoral edema will cause compression of the nearby brain tissue. The volume of the cranial cavity is fixed, and the compression will increase the intracranial pressure to a certain extent. Most of the patients with glioma have cranial hypertension, the main symptoms are headache and vomiting. If these conditions occur, cranial hypertension caused by glioma should be considered. Mannitol is the most cost effective and commonly used drug to lower cranial pressure. If the tumor can be surgically removed after the diagnosis is made, it is better to remove the tumor first to relieve the cranial hypertension, and also to clarify the nature of the pathology. If surgery is not possible or if the patient is post-operative, then most of the patients will be treated with symptomatic drugs such as mannitol, and if the edema is caused by radiotherapy, then hormones or bevacizumab can be given.