I propose that the ideal solution for liver cancer treatment is multidisciplinary holistic treatment. The core connotation of tumor MDHT strategy is the patient-centered holistic unification of the three major medical sciences in terms of disease diagnosis and understanding (treatment goal), disease-centered multidisciplinary integration in terms of treatment method selection (treatment method), and technology-centered coordination in the process of diagnosis and treatment practice (treatment course). The objectives of holistic tumor treatment include six basic objectives, such as local lesions, regional lesions, systemic lesions, organ-based diseases, systemic internal environment and rehabilitation; the design of tumor MDHT program should follow six basic principles, such as systematic, comprehensive, economic, standardized, individualized and dynamic. In the implementation of holistic treatment, Western medicine should be the mainstay, Chinese medicine should be the auxiliary, and the combination of Chinese and Western medicine should be the synergy, and the three medical methods should be organically combined into one. The 2011 edition of the “Standard for the Treatment of Primary Liver Cancer”, completed under the auspices of the Ministry of Health of the People’s Republic of China, provides most of the relevant protocols, but it is not enough to meet the needs of holistic treatment. The following are examples of how to design and implement MDHT protocols for hepatocellular carcinoma according to MDHT strategies. A patient with hepatocellular carcinoma, male, 52 years old, with normal heart, lung, brain and other extrahepatic organ functions. A relatively comprehensive clinical history, laboratory results and imaging data were collected. The treatment plan process could be planned and designed at different periods of the treatment process as if it were a construction schedule. According to the requirements of MDHT strategy, we first made systematic diagnostic analysis from six aspects as follows: ① primary hepatocellular carcinoma, single nodule diameter 4.5cm, tumor located in segment VIII near the second hepatic hilar, international TNM stage II (cT2N0M0); ② no satellite foci or metastases were seen in liver imaging; ③ no abdominal and body surface lymph node enlargement and no extrahepatic metastases were found; because the tumor was larger than 3cm, according to tumor biological characteristics of peripheral blood with free cancer cells, the possibility of potential metastasis; ④ post-hepatitis cirrhosis (moderate), hepatitis B virus DNA of 1×106copies, Child-Pugh liver function grade A; ⑤ immune function is low, peripheral blood CD3+ T-cell ratio increased, CD4+/CD8+ ratio inverted; ⑥ general general condition is good, weight loss 5Kg According to the treatment objectives of MDHT strategy and the principles of treatment selection, the treatment plan was formulated with reference to the relevant guidelines for the treatment of liver cancer, guidelines for the treatment of liver disease and rehabilitation guidebooks. Western medicine is the mainstay, and the first stage is to treat the liver cancer lesions, maintain liver function and regulate the internal environment, while the subsequent treatment is to prevent recurrence and metastasis. Maintaining the dynamic balance of the body’s internal environment is the main way to prevent tumor and survive with tumor, among which the overall regulation of Chinese medicine is an important means to maintain the balance of the body’s internal environment. The therapeutic advantage of TCM lies in the whole body internal environment regulation, which should be combined with “individualized treatment” and “holistic treatment”, that is, according to the patient’s disease progress and the state of evil and positive, different treatment strategies should be adopted in different stages; when to mainly support positive and when to mainly eliminate evil should be based on specific circumstances. When to focus on helping the positive and when to focus on eliminating the evil should be determined according to the specific situation. The treatment of TCM formulas or proprietary medicines should be interspersed or accompanied by the treatment process of Western medicine, taking into account the treatment situation in all aspects, and the diagnosis and treatment should be adjusted at any time, such as the treatment of the primary lesion, intrahepatic invasion or metastasis and systemic metastasis, and the control of liver diseases such as hepatitis and cirrhosis, etc. Combined Chinese and Western medicine treatment should first accurately determine the remaining problems or new problems arising after treatment by Western medicine and Chinese medicine, and then give targeted treatment to further improve the overall efficacy after treatment by Western medicine and Chinese medicine. For example, some Chinese patent medicines and intravenous Chinese medicine preparations for chemotherapy reaction or cirrhosis are examples of combined Western and Chinese medicine treatment. For the above cases, the MDHT process integrating TCM, Western medicine and combination of Chinese and Western medicine mainly includes (Figure 2): ① targeting liver cancer lesions: choosing radical resection of liver cancer lesions or performing radiofrequency ablation according to NCCN guidelines [20] or domestic liver cancer guidelines [23]; ② when there is no clear intrahepatic recurrence of metastasis, intermittently giving anti-cancer Chinese medicine treatment and chemoembolization every six months after surgery for a total of 3 courses of treatment (3) For potential tumor dissemination, intermittent anti-cancer proprietary Chinese medicine treatment; 3 courses of DC-CIK cell therapy; once extra-hepatic metastases are detected, corresponding treatment will be given; (4) For chronic liver disease, reference should be made to the relevant liver disease guidelines [24,25] for staged anti-hepatitis B and C virus and anti-liver fibrosis treatment, combined with (5) internal environment regulation, intermittent administration of immune factor thymidine alpha, combined with proprietary Chinese medicine treatment; (6) rehabilitation treatment combined with a variety of means, including psychological counseling, physical adjustment, and improvement of diet and life. (7) Chinese medicine diagnosis and treatment is used in all stages of the overall treatment, and the interval between the above treatments is the space for implementing Chinese medicine treatment, which can reduce the adverse effects between multiple treatments when implemented at the same time. And the combination of Chinese and Western medicine treatment needs to be selected as needed in the process of MDHT.