The clinical diagnostic criteria for bone metastases are: 1. a definite history of primary malignancy; 2. 99 Tc-MDP whole-body bone imaging reveals multiple irregular foci of abnormal radioactive concentration or hypoplasia of bone tissue, and follow-up reveals the persistence or further expansion of the lesions; 3. X-ray, CT or MRI examination reveals local bone tissue with osteolytic or osteogenic 3. local osteolytic or osteogenic destruction or pathological fracture was found on X-ray, CT or MRI; 4. pathological examination of the bone lesion was confirmed. The diagnosis of bone metastases can be made by meeting any two of 1, 2, 3, or 4. A single or suspicious lesion should be followed up for six months to two and a half years or more until the diagnosis is confirmed.