Chronic nephritis eat anti-inflammatory drugs that have less or no renal impact, mainly semi-synthetic penicillin, such as piperacillin and meloxicillin, cephalosporin III and above, ceftriaxone, ceftazidime, cefoperazone, cefepime, macrolides of roxithromycin, azithromycin, carbapenem antibiotics, imipenem, biafenan, tetracycline antibiotics, doxycycline. Patients who have chronic nephritis, if the infection requires anti-infective treatment, it is recommended to use the above drugs for anti-infective treatment, such as semi-synthetic penicillin for skin soft tissue infections. If the lung infection or urinary tract infection, it is recommended to use cefadroxil, ceftriaxone, ceftazidime. If the infection is more severe, with sepsis, infectious shock, and bacterial culture suggesting Gram-negative bacillus infection, carbapenem antibiotics such as imipenem and biexpenem are used.