Glucocorticoids are known to inhibit androgen secretion due to hyperadrenocorticism, and have anti-inflammatory and immunosuppressive effects. Oral glucocorticosteroids are mainly used for fulminant acne or comedogenic acne because these types of acne are often associated with excessive immune response and inflammation, and brief use of glucocorticosteroids can provide immunosuppressive and anti-inflammatory effects. However, care should be taken that glucocorticoids themselves are anti-inflammatory and trigger acne. Oral administration is only available for patients with more severe inflammation and in small amounts for short-term use. Recommended dosage: 1. Fulminant acne: Prednisone 20-30 mg/d for 4-6 weeks, followed by a gradual reduction in dosage over 2 weeks, with the addition of oral retinoic acid. 2, Aggregative acne or acne fulminans with exacerbation during oral treatment with retinoic acid, give prednisone 20-30 mg/d for 2-3 weeks, followed by gradual dose reduction within 6 weeks; at the same time, discontinue oral retinoic acid or reduce the dose to 0.25 mg/(kg.d), then increase or decrease the dose according to the condition. 3. Prednisone 5 mg/d or dexamethasone 0.375-0.75 mg/d, taken every night, is an anti-inflammatory to inhibit the high secretion of pro-adrenal hormones early in the morning and inhibit the production of androgens by the adrenal glands and ovaries, and is gradually reduced after improvement. For patients with acne that worsens before menstruation, prednisone 5 mg/d can be started 10 d before menstruation until the onset of menstruation. Fisher et al. suggested that high doses of glucocorticoids have anti-inflammatory effects, while low doses have anti-androgenic effects.