The diagnosis of gallstones is based on several manifestations. First, symptoms, mainly manifested as epigastric discomfort or biliary colic, which are clinical manifestations. Second, according to the physical signs, the physician will find that the patient with gallstones has pressure pain in the right upper abdomen or middle and upper abdomen, called Murphy’s sign, and when the gallbladder is enlarged, Murphy’s sign is positive, a typical manifestation. Thirdly, the most common test is ultrasound, which often reveals an enlarged gallbladder, stones in the gallbladder, thickening of the gallbladder wall, and in acute attacks, ultrasound will reveal single or multiple stones in the gallbladder. Of course, there are further tests, such as CT and MRI. The main thing is to go to the hospital when the symptoms appear and ask the specialists and professionals to help you with the diagnosis.