The role of androgens in the female body

  According to scientists, the daily production of testosterone in adult women is about 1/20 of that in men, and the amount in the blood is about 1/10 of that in men. androgens in women are mainly produced by the ovaries and adrenal glands, in addition, androstenedione, an intermediate product of estrogen synthesis by the ovaries, can also be converted into androgens in the peripheral tissues. In women of reproductive age, the main androgens in the blood circulation are testosterone, androstenedione and dehydroepiandrosterone, among which testosterone has the strongest physiological activity.  The role of androgens in women’s body includes the following aspects: 1. Androgens are the precursors of synthetic estrogens, so promoting estrogen synthesis is the main function of androgens in women’s body.  2.Maintain the normal reproductive function of women.  3.To maintain the normal development of female pubic hair, axillary hair, muscles and the whole body.  4.The rapid growth of young girls during puberty also has the influence of androgens.  5.Maintain normal female sexual desire, good mood and maintain memory and bone growth.  Besides, androgens can also act on kidney and extra-renal tissues to increase erythropoietin and strengthen bone marrow hematopoiesis. Therefore, androgens can also be used to treat aplastic anemia or anemia of excessive menstruation.  However, if androgens are overproduced in women, they can inhibit the secretion of gonadotropin-releasing hormone by the hypothalamus and counteract estrogen, causing ovarian function to be inhibited and non-ovulation, amenorrhea, and even masculine manifestations. It can also lead to endocrine disorders and cause acne and hirsutism, such as polycystic ovary syndrome.  Second, what are the side effects of androgens?  Androgenic effects may include acne, increased hair, increased libido in men, low voice in women, enlarged clitoris, reduced breast size, and menopause, and liver function damage, but it is easy to recover after stopping the drug. Sometimes there are edema, gastrocnemius muscle spasm and insomnia, and children are prone to penile erection and accelerated skeletal maturation.  Current studies have shown that androgens and estrogens have synergistic effects in women with hypovarianism or perimenopause. In estrogen deficiency, the bioavailability of androgens can be increased due to alterations in sex hormone binding globulin. In postmenopausal women, studies recommend a better regimen of combined estrogen-androgen therapy based on the protective effect of androgens on bone, but only at physiological doses to avoid the side effects of excessive androgens. In conclusion, androgens play an essential role in female growth and reproductive function, and the mechanisms involved and the interactions with other hormones need to be further investigated.