With the improvement of drugs and chemotherapy regimens, many patients will have a better outcome after regular chemotherapy, and will be able to save their limbs or lives. Currently, the five-year survival rate in China is 70 to 80 percent after regular treatment. Does osteosarcoma still cause pain and other symptoms after treatment? Generally speaking, if osteosarcoma is effective after chemotherapy, the pain symptoms will disappear; if the pain still exists after chemotherapy, it means that the chemotherapy is not effective, which may be due to a poor protocol or the patient’s intolerance to chemotherapy.