Biologic therapy is not the main treatment direction for osteosarcoma. In fact, the internationally accepted treatment option for osteosarcoma is still neoadjuvant chemotherapy + surgery. Targeted therapies have not been specifically targeted for osteosarcoma since the beginning of their development. Therefore, for osteosarcoma, even if a few patients produce results with a certain targeted therapy, this is not its main treatment method. Because targeted therapy must find the corresponding target in order to work, and at present, there is no very clear target for osteosarcoma.