Mr. Wang, 52, recently felt that one side of his nasal cavity was not ventilated, and went to the hospital to find out that the culprit was actually a swelling in his nasal cavity, and after pathological examination, nasal polyps were ruled out, and not the horrible nasal cancer, but “involuted papilloma”. So, here is Mr. Wang’s question: 1. Is nasal sinus involute papilloma caused by human papilloma virus (HPV) infection? The answer is: not exactly. The cause of involuted papilloma is not fully understood. It is associated with human papillomavirus (HPV) infection in 33-42% of cases, and the main virus subtypes associated with it are 6, 11, 16 and 18. 2. Is involuted papilloma of the nasal sinuses associated with malignancy? The answer is: in the Western literature, malignancy is diagnosed in 7-8% of patients with a diagnosis of involuted papilloma and in less than 3% of patients with either early or late diagnosis of malignancy. 3. Can involuted papilloma of the nasal cavity and sinuses be cured by surgery? The answer is: the cure rate is related to the site of tumor growth. The cure rate for tumors with roots in the nasal cavity is higher than that for tumors with roots in the sinuses; for tumors growing in the sinuses, the cure rate for sinus tumors near the nasal cavity is higher than that for tumors far from the nasal cavity. 4. Is the surgical treatment of nasal sinus invagination papilloma disfiguring? The answer is that, depending on the advancement of technology, most of the endoscopic surgery for nasal sinus invagination papilloma can now be performed by nasal endoscopy, which means that surgical access can be provided through the natural orifice of the nostril, avoiding the problem of facial scarring caused by incisions on the face and lips. 5. What happens after a recurrence of nasal sinus invagination papilloma? The answer is: reoperation is recommended if there is a chance of surgery. One is for treatment, and the other is for timely detection of malignancy so that better treatment options can be provided in a timely manner.