Hepatocellular Carcinoma Interventional Treatment Topic VI: What are the adverse effects after interventional treatment?

  The various methods of liver cancer interventional therapy have been introduced to all patients, today let us talk about the adverse reactions and points to note after interventional therapy, hope it will be helpful to you.  I. What are the common adverse reactions of interventional treatment?  1.Local bleeding at the site of the puncture wound Local bleeding at the postoperative wound is mostly seen within 24 hours after the operation, mainly manifested as hematoma and ecchymosis around the puncture wound. For patients with femoral artery puncture, compression of the puncture site is required, and postoperative lower limb braking and bending are prohibited. In general, patients can get out of bed after 24 hours after the intervention, while those with poor coagulation mechanism, elderly people, and those with multiple punctures should avoid premature bed activity and increased abdominal pressure, and keep the bowels open to prevent wound bleeding.  2. Fever Fever is a common clinical symptom of post-interventional patients. Due to the embolization of blood supply artery of liver cancer, local tumor ischemia and necrosis will lead to fever absorption, which is a normal phenomenon, mostly appearing on the second day after surgery, reaching the peak in 3-5 days, and will be relieved after a week. For the patients with low fever, physical cooling is the main purpose and encourage to drink more water; for moderate and medium fever or above, you can follow the medical advice to take Xinhuang tablets or give antipyretic and analgesic drugs, such as indomethacin bolus to reduce fever.  3.abdominal pain The occurrence of abdominal pain is related to ischemia of embolism site, necrosis and edema of tumor cells, increase of liver volume and tension of envelope. If the pain is mild, the patient can communicate with family members to divert their attention and eliminate the tension; if the pain is moderate to severe, the patient can use pain relief drugs as prescribed by the doctor for symptomatic treatment.  4, nausea and vomiting Most of the nausea and vomiting is caused by the gastrointestinal reaction caused by chemotherapy drugs. For patients with more frequent vomiting, postoperative antiemetic agents can be applied to reduce symptoms. When vomiting occurs, the head should be tilted to the side to avoid choking or even asphyxiation caused by inadvertent aspiration of vomit into the bronchus.  5. Abnormal liver and kidney function The application of chemotherapeutic agents and embolic agents in interventional treatment can cause damage to liver cells, while some chemotherapeutic drugs such as cisplatin and contrast agents used in interventional procedures can lead to impaired kidney function. For most patients, abnormal liver and kidney functions are mostly transient, mainly manifested by different degrees of alterations in bilirubin, ghrelin, glutamic aminotransferase, alkaline phosphatase, albumin, etc., which appear on the 2nd-5th day after intervention and return to normal around 7-10 days. For post-interventional patients, it is recommended to drink more water (except for patients with ascites) to facilitate the excretion of chemotherapy drugs and contrast agents, and to routinely apply liver and kidney-protective drugs to promote the recovery of liver and kidney functions.  6, infection For patients with poor resistance, the application of chemotherapeutic drugs can lead to bone marrow suppression and cause secondary infection. For patients with persistent high temperature that does not subside after interventional treatment, blood culture examination can be given to exclude the possibility of infection and antibiotic treatment can be given according to the test results.  7. Gastrointestinal bleeding Many patients with hepatocellular carcinoma combined with cirrhosis have elevated portal vein pressure, which is manifested as esophagogastric fundic varices. After nausea and vomiting after intervention, it is easy to induce gastrointestinal bleeding, which is manifested as vomiting blood and black stool. In this case, patients need to fast immediately and apply symptomatic treatment with drugs to reduce portal pressure, such as growth inhibitor or terlipressin.  What do patients with liver cancer undergoing interventional treatment need to pay attention to in their life?  Patients with hepatocellular carcinoma undergoing interventional treatment should, first of all, avoid taking drugs that are harmful to liver function after the operation. In terms of diet, there are actually not too many contraindications after interventional treatment, and the main recommendation is high-protein soft food. Properly eating more protein including animal protein helps recovery, such as lean meat, fish, river shrimp, etc. Due to the poor digestive function of liver cancer patients, they can eat less and more meals. In addition, do not eat hard or rough food to avoid inducing gastrointestinal bleeding.