Testicular asymmetry, which is characterized by one side of the scrotum being pendulous and the other side being higher than the opposite side, may be a normal physiological phenomenon; pathological factors are mainly related to varicocele and testicular syringomyelia. The two testicles are normally asymmetrical, not identical. If there is no other discomfort, no treatment is needed. Varicocele is caused by abnormal tortuosity of the spermatic cord’s trailing venous plexus and blood stagnation, which may manifest as scrotal sagging, swelling and pain. One side of the testis may decrease in size, which can cause asymmetry between the two testes, and high spermatic vein ligation can be performed as needed. Testicular syringomyelia refers to the formation of increased fluid in the syringomyelia cavity. There are usually no uncomfortable symptoms. Typical symptoms are scrotal prolapse, painless swelling, spermatic cord traction pain, etc. It often manifests as asymmetry of testicles on both sides. Commonly used surgical methods include sheath reversal surgery. If you find asymmetry of testicles on both sides, you should consult a doctor in time, and should not take medication without authorization in order to avoid delaying the condition. You should pay attention to rest on weekdays, quit smoking and drinking, and maintain a regular routine.