Hepatitis B antibodies include hepatitis B surface antibody (anti-HBs), hepatitis B e antibody (anti-HBe), and hepatitis B core antibody (anti-HBC) in the five hepatitis B tests. Hepatitis B surface antibodies: they begin to appear some time after the hepatitis B surface antigen (HBsAg) turns negative in the late stage of acute infection, and gradually rise to a peak within 6-12 months, which can last for many years, but the titer will gradually decrease; in about half of the cases, hepatitis B surface antibodies can be detected several months after the hepatitis B surface antigen turns negative; in a few cases, hepatitis B surface antibodies are never produced after the hepatitis B surface antigen turns negative. Positive hepatitis B surface antibody indicates immunity to hepatitis B virus, which can be seen in the recovery period of hepatitis B, previous infection and after hepatitis B vaccination Hepatitis B e antibody: indicates that viral replication is mostly in a quiescent state and the infectiousness is reduced, but some patients have viral replication and hepatitis activity. However, long-term positive hepatitis B e antibody does not mean that virus replication has stopped or is not infectious. Hepatitis B core antibodies: Hepatitis B core antibodies can be detected in almost all people infected with hepatitis B virus. Hepatitis B core antibody IgM is an antibody that appears earlier after HBV infection, and a positive result indicates an acute phase or an acute attack of chronic hepatitis. Therefore, each of the three hepatitis B antibodies has a different significance, and different combinations of the five hepatitis B items are commonly used clinically to determine the status and regression of infection.