The length of time between the onset of glioma grade IV and death is highly dependent on the location of the tumor, one’s own physical condition, treatment and the severity of the disease, which generally ranges from six months to several years. Glioma grade IV is highly malignant, its borders are usually blurred, it grows very fast, is prone to recurrence, has a poor prognosis, and has a short survival time. Glioma is a relatively difficult disease to cure, and the outcome of treatment is related to the disease, age of onset, patient’s physical condition and other factors. Surgery, radiotherapy and chemotherapy are the main treatments for glioma, and some patients may also experience recurrence and drug resistance after treatment. Patients with glioma grade IV should actively cooperate and receive standardized treatment, and at the same time, they should pay attention to maintain good living habits, not to smoke, not to drink alcohol, not to stay up late, to ensure sufficient sleep, reasonable and healthy diet, and avoid intense emotional fluctuations.