Although hemangiomas are common, our understanding of their pathogenesis is still in its infancy. It is generally believed that they are the result of the interaction of multiple factors, such as genetics and environment, and that the following factors are associated with hemangioma development. 1. placental “embolism” hypothesis 2. hypoxic mechanism 3. angiogenic peptide 4. hemangioma stem cells 5. β-adrenergic receptor 6. soluble cytokine theory 7. gene mutation theory 8. endothelial progenitor cell theory The most common predisposing factors for hemangioma are: ① Caucasian; ② female (71% female or 2.4:1 female to male ratio) The most common predisposing factors for hemangioma are: (1) Caucasian; (2) female (71% female or 2.4:1 female to male ratio); (3) low birth weight; (4) multiple pregnancy. The presence of advanced maternal age and placenta praevia have also been shown to be significant factors. The most significant risk factor has been identified by multivariate analysis as low birth weight infants . In contrast, focal hemangiomas occurring in low birth weight infants are more common than nodes, and low birth weight increases the risk of multiple hemangiomas .