Chronic renal failure is the end result of progressive development of various kidney diseases. With the progression of chronic renal failure, patients may gradually show manifestations of systemic multisystem damage, involving multiple systems such as digestive, hematological, cardiovascular, respiratory, neurological, immunological, endocrine, skeletal and muscular, as well as water, electrolyte and acid-base imbalance. Patients with end-stage renal failure rely mainly on renal replacement therapy. Until then, it is important to pay attention to conservative therapy (non-dialysis therapy) to delay the progression of renal failure, reduce its prevalence and morbidity and mortality, and improve the quality of life of patients. The main measures of conservative therapy for chronic renal failure are: 1, early diagnosis and treatment of renal primary disease, correct understanding and treatment of the characteristics and development of the disease; 2, avoid or remove factors that aggravate renal damage, including drug factors; 3, can consider the application of traditional Chinese medicine rhubarb preparations and wormwood preparations to delay renal fibrosis; 4, early in the disease, can consider the use of the use of renin-angiotensin- 4, in the early stage of the disease, you can consider using antihypertensive drugs in the renin-angiotensin-aldosterone system to slow down the progression of renal lesions and reduce proteinuria; 5, change the lifestyle, quit smoking and alcohol, control weight; 6, high quality low protein diet, with the use of essential amino acids and keto acids; 7, stabilize the internal environment, prohibit high potassium, high phosphorus, high purine food, maintain acid-base balance; 8, pay attention to the prevention and treatment of other organ functions: cardiovascular system, digestive system, skeletal system; test Hematocrit index, use erythropoietin to correct anemia; 9, supplement active vitamin D; 10, family mobilization, patients actively participate in health science education, prepare for renal replacement therapy.