The health of newborn babies is a concern for many mothers. Neonatal hemolysis is caused by many reasons, mostly by ABO and RH blood group system incompatibility, which simply means that the fetus is of a different blood type from the mother, resulting in rejection, thus leading to hemolysis. Hemolytic disease has symptoms such as anemia, hepatosplenomegaly, fever, and in severe cases, bleeding and death, which must be detected, prevented and treated in time; neonatal hemolytic disease can be treated by intravenous drip, blood exchange and phototherapy, etc. Early detection can lead to timely diagnosis and cure, but if detected late, it may lead to severe anemia and thus death. Therefore, timely detection and treatment, as well as prevention, are the keys to treating hemolysis. In order to ensure the health of newborns and prevent hemolysis, pregnancy tests and hemolysis tests should be done in a timely manner, and older pregnant women and pregnant women with Rh blood type should pay more attention to the fact that after the birth of a newborn, the child should be given frequent and effective breastfeeding, change clothes and bathe regularly, and take good care of all parts of the body. For the physical and mental health of the baby, parents must do a good pre-conception checkup, which is essential, do not delay the baby’s life in order to save.