1. There are four ways in which drugs affect male fertility: 1. they act directly on the male gonads, affecting the sperm-producing spermatogenic cells of the testes and the function of testicular Leydig cells; 2. they act on the hypothalamic-pituitary-gonadal axis, affecting the normal secretion of hormones in the body, leading to changes in gonadotropin and testosterone levels, ultimately affecting fertility; 3. they impair the function of sperm discharge; 4. they have a negative impact on male libido . Second, the impact of male fertility drugs are: 1, immunosuppressive drugs: the impact on fertility with the type of drugs, dose and time of use. These drugs include cyclophosphamide, vincristine, Adriamycin, vincristine, nitroprusside, nitrogen mustard, procarbazine hydrochloride, cisplatin and etoposide. Cyclophosphamide causes damage to male germ cells, often resulting in irreversible reduced fertility. Methotrexate has no significant effect on spermatogenesis, but may lead to reversible infertility; discontinue 3 months before planning pregnancy. Leflunomide has little effect on male fertility, and due to the lack of sufficient information, it is currently recommended that men taking leflunomide and wanting to have children may refer to the protocol for female patients and take abciximide 8 g, 3/d for 11 d. Azathioprine, cyclosporine A, or mortifamate do not appear to reduce male fertility, but cyclosporine can cause a decrease in sperm density and viability. 2, antihypertensive drugs: most of them mainly impair sexual function, such as certain diuretics can cause erectile dysfunction by reducing vascular resistance, resulting in inadequate blood supply to the penis; beta-blocker insulin can affect the libido and erectile function; anisodone affects fertility by affecting erectile function and libido and the potential impact on semen quality; calcium channel blockers can inhibit the normal fertilization process. 3, sex hormone drugs: anti-androgen drugs make the body androgen normal physiological function is affected (libido decline and sperm production disorders), causing fertility problems. More and more athletes abuse anabolic steroids, such as a large number of synthetic androgens can lead to low gonadotropin hypogonadism, in most cases after stopping the drug can restore normal gonadal function. 4, other drugs: some antibacterial agents such as neomycin, erythromycin, gentamicin, etc. may cause a decrease in semen quality. Colchicine and allopurinol for the treatment of gout also have an adverse effect on male fertility. Furacilin, cimetidine, salazosulfapyridine, cocaine, nicotine and cannabis can impair spermatogenesis, but spermatogenesis and/or sperm function can return to normal after cessation of the drug. Lyuzosulfapyridine can affect late sperm maturation, and sperm quality can be restored after 2 to 3 months of discontinuation, enabling successful conception. Exposure to environmental toxins such as pesticides should also be noted.