”Hormone-refractory prostate cancer is a type of “hormone-independent prostate cancer” that does not respond to second-line hormone therapy or continues to progress during second-line hormone therapy. This type of prostate cancer does not respond to second-line hormone therapy or continues to progress during second-line hormone therapy. “This type of prostate cancer is collectively known as desmoplastic prostate cancer. These prostate cancers are collectively known as destructive resistant prostate cancer.