The incidence of urinary stones in pregnant women was reported by Srirangam et al. to be 0.05% to 0.40%. The true incidence of combined urinary stones in pregnancy is not well known because most patients present with symptoms of colic before they are seen, and some patients who do not present with symptoms are not detected in time. The susceptibility to stone formation during pregnancy is generally believed to be due to changes in the normal anatomy of the urinary system during pregnancy and changes in calcium and phosphorus metabolism in pregnant women; together with the increased level of progesterone and the influence of autonomic function during pregnancy, causing a decrease in smooth muscle tone in the urinary system, dilatation of the ureter and significantly weaker peristalsis, and slow urinary flow, leading to stone formation blink. If the treatment is not timely, combined. When the infection such as pyelonephritis or premature rupture of fetal membranes, the rate of preterm delivery of pregnant women is even higher, so timely and effective analgesic, antispasmodic, anti-infective treatment is very necessary. Although surgical interventions such as the placement of double J-tube can be used to treat pregnancy-associated recalcitrant renal colic, and the efficacy of the treatment is exact, most pregnant women and their families still have concerns about surgical treatment and refuse it; at the same time, some studies have shown that about 70% to 80% of urinary stones in pregnant patients can be expelled naturally, so the first goal should be to relieve the symptoms and not deliberately pursue stone cure, that is, to take Conservative treatment. Although the clinical use of drugs is limited in consideration of the safety of pregnant women and fetuses, appropriate conservative management of drugs can both relieve the patient’s pain and protect the fetus from miscarriage and preterm delivery. Among them, scopolamine (654-2) and progesterone have been used clinically for many years, and neither has been reported to be significantly harmful to pregnant women and fetuses, indicating that they are safe for pregnant women and fetuses. Scopolamine is the antispasmodic of choice in the clinical treatment of renal colic. It has a peripheral anti-M-choline receptor effect and can release smooth muscle spasm caused by acetylcholine. It can relax the smooth muscle of ureter and relieve renal colic, but the effect is limited when used alone; moreover, when the dose is too large, it is easy to have side effects such as rapid heartbeat, blurred vision, dizziness, blurred eyes and dry mouth, and even induce intestinal paralysis and intestinal obstruction, which affects the therapeutic effect; while progesterone can relax the spastic smooth muscle of ureter, and at the same time has the effect of diastolic smooth muscle of uterus, which has both antispasmodic and antifetal functions, and also antagonizes aldosterone sodium excretion It is suitable for the treatment of stone colic attacks during pregnancy; moreover, the combination of progesterone and scopolamine can significantly reduce the dosage of scopolamine, thus reducing the occurrence of scopolamine side effects. All of our data had been first injected with scopolamine 10mg and progesterone 20mg intramuscularly, but the analgesic effect was limited and renal colic was persistent. The reasons for this are related to the increase of progesterone in the body during pregnancy, which reduces the tone of the smooth muscle of the urinary tract and weakens the peristalsis of the renal pelvis and slows down the urine flow; the increase of pressure in the renal pelvis due to the compression of the ureter by the enlarged uterus; and the difficulty of passing the stones through the three physiological stenoses of the ureter (the pelvic ureteral junction, the crossing of the iliac artery and the bladder wall), which cause obstruction; together with the anxiety and tension of the pregnant women caused by pain, the body’s The body is also less reactive and tolerant. This weakens or counteracts the smooth muscle antispasmodic and analgesic effects of scopolamine and progesterone, as well as the sodium-removal diuretic effects. If scopolamine and progesterone do not provide relief of renal colic in such women, m-triophenol (Phloroglucinol) should be added promptly. Phloroglucinol has been used in Europe for more than 40 years and in China for nearly 10 years. Its rapid antispasmodic effect, significant effect and low adverse effects have been widely recognized, and the clinical application results over the years have shown that it has no adverse effects on the mother and fetus, which proves that it is safe to be used in pregnancy and renal colic. The present data also show that the effect of combining mebendazole to control acute renal colic is more significant than that of scopolamine and progesterone alone, because mebendazole is a pro-muscular antispasmodic, which only acts on the spastic smooth muscle and has only a minimal effect on the normal smooth muscle. In acute renal colic, the smooth muscles of the genitourinary tract are in pathological spasm, and ask benzotriophen acts on the spastic smooth muscles, and relieves the colic by relaxing the spastic smooth muscles. If the pain is still not relieved, pethidine 75-100mg of opioid can be injected intramuscularly, but caution should be exercised when using pethidine near the due date to avoid causing fetal respiratory depression. Non-steroidal anti-inflammatory analgesics can block prostaglandin synthesis in the fetus, which can easily lead to premature closure of the fetal ductus arteriosus and the risk of fetal pulmonary hypertension, so their use should be prohibited. For patients with intractable renal colic in pregnancy complicated by irregular contractions of the uterus and vaginal bleeding, it is appropriate to apply magnesium sulfate treatment in time, because: (1) intractable renal colic in pregnancy complicated by irregular contractions of the uterus and vaginal bleeding, mainly related to the uterine meconium and endometrial local production of prostaglandins, and magnesium sulfate can block the synthesis and release of prostaglandins, while magnesium ions can reduce the release of neurotransmitters , reduce the excitability of the myometrium, thus relaxing the uterine smooth muscle, play a role in fetal preservation; (2) magnesium ions into the blood circulation also act on the renal pelvic ureter, relaxing the smooth muscle of the renal pelvic ureter; at the same time block the synthesis and release of prostaglandins in the kidney, affecting the glomerular filtration rate, reduce. Renal pelvic pressure, relieve renal colic; (3) magnesium ion can also affect the solubility of calcium oxalate, reduce crystal precipitation, promote stone dissolution; (4) magnesium ion into the extracellular fluid, can inhibit the central nervous system, can also reduce the release of motor nerve endings acetylcholine, block the peripheral neuromuscular junction, produce sedation, antispasmodic, relaxation of muscle, thus relieving patients irritable tension, facilitate pregnant women The effect of magnesium sulfate can be improved by cooperating with the treatment. To sum up, magnesium sulfate has good effect of relaxing smooth muscle, relieving renal colic, promoting lithotripsy, preventing contraction and calming fetus, which is suitable for the treatment of intractable renal colic during pregnancy. But in the use of magnesium sulfate should pay attention to the speed of intravenous infusion, to 1-2g/h is appropriate, the first intravenous drip can double the dose of 4g/h. At the same time, closely observe the patient’s heart rate, m pressure, respiration, urine volume and knee reflex, to prevent overdose poisoning. Any heart rate <60 times/min, urine volume less than 25-30 ml/h, hypotension, hypocalcemia and renal insufficiency should be prohibited. If the dose is too high or the drip rate is too fast which may cause a drop in blood pressure, respiratory depression, weakening or disappearance of knee reflex, the drug should be stopped immediately and the calcium should be slowly injected for relief. Patients with pregnancy and renal colic have more or less urinary tract obstruction, which is more likely to cause infection, and inflammation will aggravate the condition of renal colic. A vicious circle is formed, and sepsis can occur in severe cases, seriously affecting the safety of the pregnant woman's fetus. Therefore, if clinical symptoms (urinary tract irritation signs, etc.) and test results (blood and urine routine) suggest the presence of infection, or combined with appendicitis, antibiotics should be applied promptly. It is best to apply antibiotics based on the results of drug sensitivity tests, but this is generally not possible in emergency medicine and is often used empirically in clinical practice. Urinary tract infections are mostly caused by Gram-negative bacilli such as Escherichia coli, and penicillins or third-generation cephalosporin antibiotics are both sensitive to Gram-negative bacilli and safe for the fetus, so they are commonly used for urinary tract infections during pregnancy. With these treatments, almost all patients with pregnancy and intractable renal colic can have their pain relieved, and with close observation, most patients can safely survive the pregnancy and wait for delivery before further treatment of stones. For those who have failed conservative treatment or have acute renal failure due to stone obstruction or serious infection, surgical treatment is required.