Sciatic nodule cyst should be differentiated from the following diseases: first, pear-shaped muscle syndrome, the onset site of pear-shaped muscle syndrome is similar to the onset site of sciatic nodule cyst, but pear-shaped muscle syndrome can often be accompanied by symptoms of sciatica in the lower extremities, which can appear numbness and pain in the lower extremities, then the relevant electromyography examination and nuclear magnetic and ultrasound examination can be performed to make a differential diagnosis; second, tumor of the sciatic node, when there is a tumor in the sciatic node, it can also appear pain and obvious pressure pain in the sciatic node, then the relevant CT and nuclear magnetic examination of the sciatic bone should be performed to make a differential diagnosis.