Both diabetic nephropathy and refractory nephrotic syndrome will mostly present with intractable edema, accompanied by hypoproteinemia, and gradually develop at least urine or anuria. Clinically, human blood albumin is mostly supplemented to increase plasma colloid osmotic pressure and large amounts of diuretics to eliminate edema, but the input of albumin will increase glomerular hyperfiltration, as well as large amounts of diuretics will lead to electrolyte disorders, deafness, and drug resistance. We use dampness and diuretic formulas to increase renal blood flow and reduce urinary protein leakage, thus effectively achieving therapeutic effects.