Low pepsinogen 1 is usually not a major disease. When this result appears in the test, it is usually considered to be related to gastric acid secretion insufficiency, chronic atrophic gastritis and other diseases. 1. Insufficient secretion of gastric acid: when the secretion of gastric acid is insufficient, it is easy to cause indigestion, which will lead to low pepsinogen 1 test results. This is a relatively common clinical condition that can be treated with medication. Under the guidance of the doctor, you can take oral compound digestive enzyme capsule, domperidone, magnesium aluminum carbonate and other drugs for treatment. 2. Chronic atrophic gastritis: low pepsinogen 1 is the most common in atrophic gastritis, due to long-term gastric mucosa damage caused by insufficient secretion of gastric acid, and thus the results. This disease is not considered a major disease, and can be treated symptomatically if there is discomfort.