High alkaline phosphatase is not necessarily pancreatic cancer, but also other conditions, such as liver disease, bone disease, biliary tract obstructive disease and physiological high. 1. Liver disease: Liver tissue is one of the main sites of alkaline phosphatase, and liver disease can lead to high alkaline phosphatase, such as liver cancer, liver metastases, viral hepatitis, fatty liver, etc. 2. Bone disease: bone tissue is also one of the main sites of alkaline phosphatase, bone disease can also lead to high alkaline phosphatase, such as osteochondrosis, bone metastases, bone fracture patients. 3. Biliary tract obstructive diseases: alkaline phosphatase needs to be excreted through liver and biliary system, and biliary tract obstructive diseases can lead to alkaline phosphatase excretion obstacle and high alkaline phosphatase, such as pancreatic head cancer compressing biliary tract, cholangiocarcinoma obstructing bile duct and so on. 4. Physiological high: children can have physiological high alkaline phosphatase during the period of bone growth and development; besides, alkaline phosphatase can exist in embryonic tissues, and physiological high alkaline phosphatase can also occur in pregnant women. Although patients with pancreatic cancer often have high alkaline phosphatase due to compression of the bile ducts or bone metastases, pancreatic cancer cannot be identified solely on the basis of high alkaline phosphatase, and the diagnosis of pancreatic cancer requires a comprehensive evaluation of imaging and pathologic examinations. If pancreatic cancer is suspected or diagnosed, it is recommended to go to a regular hospital for comprehensive assessment of the condition and follow the doctor’s instructions to avoid delaying the condition.