Acute upper gastrointestinal bleeding is one of the serious complications after hepatocellular carcinoma intervention, although it has been reported in China, there are different opinions on its etiology and pathogenesis. The incidence of portal hypertension and esophagogastric fundic varices is high; the inactivation ability of corticosteroids and hormones in the body is low, and peptic ulcers and gastric mucosal lesions are more common. (2) Inadequate intubation of chemotherapeutic agents into the gastrointestinal tract via the gastroduodenal artery causes acute ulceration and/or exacerbates existing portal hypertension, resulting in rupture and bleeding of the small veins in the lower part of the fundic esophagus; (3) Iodine oil injected via the artery backflows into the branches of the portal vein and obstructs portal blood flow, resulting in increased portal pressure and/or exacerbates existing portal hypertension, resulting in rupture of the small veins in the lower part of the fundic esophagus. According to Renshin Nakamura, there is a traffic branch between the hepatic artery and the portal vein at the hepatic sinusoid and the surrounding vascular network, but this traffic branch does not open during angiography and small amounts of iodine oil injection. When a large amount of iodine oil fills the hepatic sinusoid, it causes changes in the hepatic microcirculation and causes the iodine oil to flow back into the portal vein through the traffic branch. However, with the clinical application of anti-5-hydroxytryptamine receptor drugs, chemotherapy drugs can rarely cause violent vomiting, so this cause is unlikely. Hou Encun, Department of Oncology, Rui Kang Hospital, Guangxi University of Traditional Chinese Medicine Treatment ① Actively expand the volume and correct shock. ②Quickly identify the cause of bleeding and stop the bleeding in time. Intravenous posterior pituitary hormone is still an effective drug for treating portal hypertension and ruptured esophageal vein bleeding in the fundus. ③Norepinephrine cold solution can be given orally intermittently to constrict the small veins of fundus and lower esophagus, which can stop bleeding. ④H2 receptor antagonists and proton pump inhibitors can inhibit the secretion of gastric acid and promote the repair of gastric mucosa. ⑤ For ruptured esophageal vein bleeding in the fundus where drug treatment is ineffective, a three-lumen double balloon introducer can be used to stop the bleeding by compression.